Tagged As: Irritable Bowel Syndrome Zoloft
Question:
I’ve been hearing about Zoloft in low dosages helps control IBS. Has anyone tried it? Does it work? Can they point me to web pages or resources where me and my Psychiatrist can go to check on the Zoloft theory?
Answer:
Try these web sites: http://www.iffgd.org/Research_2.html Try these Medical Journal articles: Title The irritable bowel syndrome. Author Francis CY; Whorwell PJ Address Department of Medicine, University Hospital of South Manchester, UK. Source Postgrad Med J, 73(855):1-7 1997 Jan Abstract Irritable bowel syndrome is a common disorder varying in severity from trivial to incapacitating. The pathophysiology and epidemiology are gradually being unraveled and it is now becoming apparent just how poor the quality of life of some of these patients can be. It is no longer acceptable practice to diagnose the condition and discharge the patient on a high fiber diet, particularly as the latter can often make the situation worse. Although hard to treat, worthwhile responses can be achieved by careful targeting of therapy to the many different facets of the disorder. JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE ISSN 0032-5473 Country of Publication ENGLAND CAS Registry Number 0 (Antidepressive Agents); 0 (Antidiarrheals); 0 (Cathartics); 0 (Parasympatholytics) Title Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience. Author Clouse RE; Lustman PJ; Geisman RA; Alpers DH Address Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri. Source Aliment Pharmacol Ther, 8(4):409-16 1994 Aug Abstract BACKGROUND: Antidepressant agents may have a therapeutic role in functional gastroenterologic disorders, but controlled investigations in irritable bowel syndrome (IBS) have not provided satisfactory practice recommendations. To help with future study design, we reviewed a five-year clinical experience with antidepressant agents in out-patients with IBS. METHODS: Presenting features, treatment course, and clinical outcome were determined from a chart review of 138 patients attending a university-based gastroenterology practice. RESULTS: Patients were treated with up to five antidepressants in separate, consecutive trials if a satisfactory end-point had not been reached. Tricyclic antidepressants were utilized 130 times, newer antidepressants 39 times, and anxiolytic-antidepressants 47 times. Improvement and complete remission in bowel symptoms occurred in 89% and 61% of patients, respectively, during antidepressant therapy. Median dosages being prescribed when remission occurred were less than those conventionally used in clinical psychiatry (50 mg/day for several tricyclic antidepressants). Age, gender, symptom duration, and presence of psychological symptoms did not discriminate those who remitted from those who did not, whereas a pain predominant symptom pattern was more commonly associated with symptom remission (P
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